Alleviating effect of lycorine on CFA‐induced arthritic pain via inhibition of spinal inflammation and oxidative stress

ABSTRACT: Chronic pain is the primary symptom of osteoarthritis affecting a patient's quality of life. Neuroinflammation and oxidative stress in the spinal cord contribute to arthritic pain and represent ideal targets for pain management. In the present study, a model of arthritis was established by intra-articular injection of complete Freund's adjuvant (CFA) into the left knee joint in mice. After CFA inducement, knee width and pain hypersensitivity in the mice were increased, motor disability was impaired, spinal inflammatory reaction was induced, spinal astrocytes were activated, antioxidant responses were decreased, and glycogen synthase kinase 3β (GSK-3β) activity was inhibited. To explore the potential therapeutic options for arthritic pain, lycorine was intraperitoneally injected for 3 days

SUBMITTER: Hu Y 

PROVIDER: S-EPMC10160920 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature