Bacterial Decolonization for Prevention of Radiation Dermatitis: A Randomized Clinical Trial.

ABSTRACT:

Importance

Evidence-based approaches for the prevention of acute radiation dermatitis (ARD) are limited, and additional strategies are necessary to optimize care.

Objective

To determine the efficacy of bacterial decolonization (BD) to reduce ARD severity compared with standard of care.

Design, setting, and participants

This phase 2/3 randomized clinical trial was conducted from June 2019 to August 2021 with investigator blinding at an urban academic cancer center and enrolled patients with breast cancer or head and neck cancer receiving radiation therapy (RT) with curative intent. Analysis was performed on January 7, 2022.

Interventions

Intranasal mupirocin ointment twice daily and chlorhexidine body cleanser once daily for 5 days prior to RT and repeated for 5

SUBMITTER: Kost Y 

PROVIDER: S-EPMC10160991 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature