Programmed cell death-1 receptor-mediated regulation of Tbet⁺NK1.1^- innate lymphoid cells within the tumor microenvironment.

ABSTRACT: Innate lymphoid cells (ILCs) play a key role in tissue-mediated immunity and can be controlled by coreceptor signaling. Here, we define a subset of ILCs that are Tbet⁺NK1.1^- and are present within the tumor microenvironment (TME). We show programmed death-1 receptor (PD-1) expression on ILCs within TME is found in Tbet⁺NK1.1^- ILCs. PD-1 significantly controlled the proliferation and function of Tbet⁺NK1.1^- ILCs in multiple murine and human tumors. We found tumor-derived lactate enhanced PD-1 expression on Tbet⁺NK1.1^- ILCs within the TME, which resulted in dampened the mammalian target of rapamycin (mTOR) signaling along with increased fatty acid uptake. In line with these metabolic changes, PD-1-deficie

SUBMITTER: Lim JX 

PROVIDER: S-EPMC10161089 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature