M₁-selective muscarinic allosteric modulation enhances cognitive flexibility and effective salience in nonhuman primates.

ABSTRACT: Acetylcholine (ACh) in cortical neural circuits mediates how selective attention is sustained in the presence of distractors and how flexible cognition adjusts to changing task demands. The cognitive domains of attention and cognitive flexibility might be differentially supported by the M₁ muscarinic acetylcholine receptor (mAChR) subtype. Understanding how M₁ mAChR mechanisms support these cognitive subdomains is of highest importance for advancing novel drug treatments for conditions with altered attention and reduced cognitive control including Alzheimer's disease or schizophrenia. Here, we tested this question by assessing how the subtype-selective M₁ mAChR positive allosteric modulator (PAM) VU0453595 affects visual search and flexible reward learning

SUBMITTER: Hassani SA 

PROVIDER: S-EPMC10161096 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature