Detecting Hexafluoroisopropanol Using Soft Chemical Ionization Mass Spectrometry and Analytical Applications to Exhaled Breath.

ABSTRACT: Here we explore the potential use of proton transfer reaction/selective reagent ion-time-of-flight-mass spectrometry (PTR/SRI-ToF-MS) to monitor hexafluoroisopropanol (HFIP) in breath. Investigations of the reagent ions H₃O⁺, NO⁺, and O₂^+• are reported using dry (relative humidity (rH) ≈ 0%) and humid (rH ≈ 100%)) nitrogen gas containing traces of HFIP, i.e., divorced from the complex chemical environment of exhaled breath. HFIP shows no observable reaction with H₃O⁺ and NO⁺, but it does react efficiently with O₂^+• via dissociative charge transfer resulting in CHF₂⁺, CF₃⁺, C₂HF₂O⁺, and C

SUBMITTER: Weiss F 

PROVIDER: S-EPMC10161230 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature