The impacts of total body irradiation on umbilical cord blood hematopoietic stem cell transplantation.

ABSTRACT:

Background

Umbilical cord blood hematopoietic stem cells are commonly used for hematopoietic system reconstitution in recipients after umbilical cord blood transplantation (UCBT). However, the optimal conditioning regimen for UCBT remains a topic of debate. The exact impact of total body irradiation (TBI) as a part of conditioning regimens remains unknown.

Objectives

The aim of this study was to evaluate the impacts of TBI on UCBT outcomes.

Design

This was a multi-institution retrospective study.

Methods

A retrospective analysis was conducted on the outcomes of 136 patients receiving UCBT. Sixty-nine patients received myeloablative conditioning (MAC), in which 33 underwent TBI and 36 did not, and 67 patients received reduced-intensity conditioning (RIC), in whi

SUBMITTER: Wang H 

PROVIDER: S-EPMC10161310 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature