Investigating the relationship between depression and breast cancer: observational and genetic analyses.

ABSTRACT:

Background

Both depression and breast cancer (BC) contribute to a substantial global burden of morbidity and mortality among women, and previous studies have observed a potential depression-BC link. We aimed to comprehensively characterize the phenotypic and genetic relationships between depression and BC.

Methods

We first evaluated phenotypic association using longitudinal follow-up data from the UK Biobank (N = 250,294). We then investigated genetic relationships leveraging summary statistics from the hitherto largest genome-wide association study of European individuals conducted for depression (N = 500,199), BC (N = 247,173), and its subtypes based on the status of estrogen receptor (ER + : N = 175,475; ER - : N = 127,442).

Results

Observational analysis suggested

SUBMITTER: Wu X 

PROVIDER: S-EPMC10161423 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature