Transcriptome-wide analysis of RNA m⁶A methylation regulation of muscle development in Queshan Black pigs.

ABSTRACT:

Background

N⁶-methyladenosine (m⁶A) refers to the methylation modification of N⁶ position of RNA adenine, a dynamic reversible RNA epigenetic modification that plays an important regulatory role in a variety of life processes. In this study, we used MeRIP-Seq and RNA-Seq of the longissimus dorsi (LD) muscle of adult (QA) and newborn (QN) Queshan Black pigs to screen key genes with m⁶A modification involved in muscle growth by bioinformatics analysis.

Results

A total of 23,445 and 25,465 m⁶A peaks were found in the whole genomes of QA and QN, respectively. Among them, 613 methylation peaks were significantly different (DMPs) and 579 genes were defined as differentially methylated genes (DMGs). Compared with the QN group,

SUBMITTER: Dou Y 

PROVIDER: S-EPMC10161540 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature