Design and synthesis of novel bis-pyridinium based-ionic liquids as potent antiparasitic agents.

ABSTRACT: Focused bis-pyridinium based-ionic liquids were successfully synthesized through the quaternization of the selected 1,2-di(pyridin-4-yl)ethane followed by metathetical anion exchange. The synthesized pyridinium derivatives were fully characterized using various NMR-spectroscopic techniques including ¹H, ¹³C, ¹¹B, ³¹P and ¹⁹F NMR. The synthesized compounds were tested for their potential effect against Toxoplasma gondii. It was revealed that compound 5 had higher antiparasitic activity compared to other compounds. Parasitic reduction percentage reached 38, 50, 77 and 79 for groups III, IV, V and VI respectively in the liver with noticed distortion and deformation in tachyzoites' shape. Surprisingly there was no statistically sign

SUBMITTER: Moneer EA 

PROVIDER: S-EPMC10161609 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature