Cooperative phototherapy based on bimodal imaging guidance for the treatment of uveal melanoma.

ABSTRACT:

Background

Uveal melanoma (UM) is adults' most common primary intraocular malignant tumor, prone to metastasis and high mortality. Eyeball enucleation commonly used in the clinic will lead to permanent blindness and mental disorders. Thus, new methods are urgently needed to diagnose and treat UM early to preserve patients' vision.

Methods and results

Herein, multifunctional nanoparticles (NPs) were synthesized by loading chlorin e6 (Ce6) in poly-lactic-co-glycolic acid (PLGA) NPs and wrapping Fe^III-tannic acid (Fe^III-TA) on the outside (Fe^III-TA/PLGA/Ce6, designated as FTCPNPs). Then, the synergistic photothermal therapy (PTT) and photodynamic therapy (PDT) antitumor effects of FTCPNPs excited by near-infrared (NIR) laser were evaluated. More

SUBMITTER: Huang T 

PROVIDER: S-EPMC10161622 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature