Probing pathways by which rhynchophylline modifies sleep using spatial transcriptomics.

ABSTRACT:

Background

Rhynchophylline (RHY) is an alkaloid component of Uncaria, which are plants extensively used in traditional Asian medicines. Uncaria treatments increase sleep time and quality in humans, and RHY induces sleep in rats. However, like many traditional natural treatments, the mechanisms of action of RHY and Uncaria remain evasive. Moreover, it is unknown whether RHY modifies key brain oscillations during sleep. We thus aimed at defining the effects of RHY on sleep architecture and oscillations throughout a 24-h cycle, as well as identifying the underlying molecular mechanisms. Mice received systemic RHY injections at two times of the day (beginning and end of the light period), and vigilance states were studied by electrocorticographic recordings.

Results

RHY enhanced

SUBMITTER: Ballester Roig MN 

PROVIDER: S-EPMC10161643 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature