DDM1-mediated gene body DNA methylation is associated with inducible activation of defense-related genes in Arabidopsis.

ABSTRACT:

Background

Plants memorize previous pathogen attacks and are "primed" to produce a faster and stronger defense response, which is critical for defense against pathogens. In plants, cytosines in transposons and gene bodies are reported to be frequently methylated. Demethylation of transposons can affect disease resistance by regulating the transcription of nearby genes during defense response, but the role of gene body methylation (GBM) in defense responses remains unclear.

Results

Here, we find that loss of the chromatin remodeler decrease in DNA methylation 1 (ddm1) synergistically enhances resistance to a biotrophic pathogen under mild chemical priming. DDM1 mediates gene body methylation at a subset of stress-responsive genes with distinct chromatin properties from conven

SUBMITTER: Lee S 

PROVIDER: S-EPMC10161647 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature