NEDD4-1 deficiency impairs satellite cell function during skeletal muscle regeneration.

ABSTRACT:

Background

Satellite cells are tissue-specific stem cells primarily responsible for the regenerative capacity of skeletal muscle. Satellite cell function and maintenance are regulated by extrinsic and intrinsic mechanisms, including the ubiquitin-proteasome system, which is key for maintaining protein homeostasis. In this context, it has been shown that ubiquitin-ligase NEDD4-1 targets the transcription factor PAX7 for proteasome-dependent degradation, promoting muscle differentiation in vitro. Nonetheless, whether NEDD4-1 is required for satellite cell function in regenerating muscle remains to be determined.

Results

Using conditional gene ablation, we show that NEDD4-1 loss, specifically in the satellite cell population, impairs muscle regeneration resulting in a significa

SUBMITTER: Cabezas F 

PROVIDER: S-EPMC10161651 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature