Elevated LILRB1 expression predicts poor prognosis and is associated with tumor immune infiltration in patients with glioma.

ABSTRACT:

Background

Leukocyte immunoglobulin-like receptor subfamily B1 (LILRB1) is regarded as an inhibitory molecule. However, the importance of LILRB1 expression in glioma has not yet been determined. This investigation examined the immunological signature, clinicopathological importance and prognostic value of LILRB1 expression in glioma.

Methods

We used data from the UCSC XENA database, the Cancer Genome Atlas (TCGA) database, the Chinese Glioma Genome Atlas (CGGA) database, the STRING database, the MEXPRESS database and our clinical glioma samples to perform bioinformatic analysis and used vitro experiments to examine the predictive value and potential biological roles of LILRB1 in glioma.

Results

Higher LILRB1 expression was considerably present in the higher WHO grade

SUBMITTER: Zou R 

PROVIDER: S-EPMC10161664 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature