Evolution and epidemic success of Mycobacterium tuberculosis in eastern China: evidence from a prospective study.

ABSTRACT:

Background

Lineage distribution of Mycobacterium tuberculosis (Mtb) isolates is strongly associated with geographically distinct human populations, and its transmission can be further impacted by the bacterial genome. However, the epidemic success of Mtb isolates at an individual level was unknown in eastern China. Knowledge regarding the emergence and transmission of Mtb isolates as well as relevant factors may offer a new solution to curb the spread of the disease. Thus, this study aims to reveal the evolution and epidemic success of Mtb isolates in eastern China.

Results

Of initial 1040 isolates, 997 were retained after removing duplicates and those with insufficient sequencing depth. Of the final samples, 733 (73.52%) were from Zhejiang Province, and 264 (26.48%) were fr

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC10161668 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature