Neural correlates of risky decision making in Parkinson's disease patients with impulse control disorders.

ABSTRACT: Some patients with Parkinson's disease (PD) experience impulse control disorders (ICDs), characterized by deficient voluntary control over impulses, drives, or temptations regarding excessive hedonic behavior. The present study aimed to better understand the neural basis of impulsive, risky decision making in PD patients with ICDs by disentangling potential dysfunctions in decision and outcome mechanisms. We collected fMRI data from 20 patients with ICDs and 28 without ICDs performing an information gathering task. Patients viewed sequences of bead colors drawn from hidden urns and were instructed to infer the majority bead color in each urn. With each new bead, they could choose to either seek more evidence by drawing another bead (draw choice) or make an urn-inference (urn choice followe

SUBMITTER: Ruitenberg MFL 

PROVIDER: S-EPMC10161684 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature