Structural analysis of the Toll-like receptor 15 TIR domain.

ABSTRACT: Toll-like receptors (TLRs) activate innate immunity in response to pathogen-associated molecular patterns (PAMPs). The ectodomain of a TLR directly senses a PAMP and the intracellular TIR domain dimerizes to initiate a signaling cascade. The TIR domains of TLR6 and TLR10, which belong to the TLR1 subfamily, have been structurally characterized in a dimer, whereas those of other subfamilies, including TLR15, have not been explored at the structural or molecular level. TLR15 is a TLR unique to birds and reptiles that responds to virulence-associated fungal and bacterial proteases. To reveal how the TLR15 TIR domain (TLR15_TIR) triggers signaling, the crystal structure of TLR15_TIR was determined in a dimeric form and a mutational study was performed. TLR15_TIR f

SUBMITTER: Ko KY 

PROVIDER: S-EPMC10161769 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature