DNA methylation at birth and fine motor ability in childhood: an epigenome-wide association study with replication.

ABSTRACT: Lower fine motor performance in childhood has been associated with poorer cognitive development and neurodevelopmental conditions such as autism spectrum disorder, yet, biological underpinnings remain unclear. DNA methylation (DNAm), an essential process for healthy neurodevelopment, is a key molecular system of interest. In this study, we conducted the first epigenome-wide association study of neonatal DNAm with childhood fine motor ability and further examined the replicability of epigenetic markers in an independent cohort. The discovery study was embedded in Generation R, a large population-based prospective cohort, including a subsample of 924 ~ 1026 European-ancestry singletons with available data on DNAm in cord blood and fine motor ability at a mean (SD) age of 9.8 (0.4) years. Fin

SUBMITTER: Serdarevic F 

PROVIDER: S-EPMC10161945 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature