Structural gray matter alterations in glioblastoma and high-grade glioma-A potential biomarker of survival.

ABSTRACT:

Background

Patients with glioblastoma (GBM) and high-grade glioma (HGG, World Health Organization [WHO] grade IV glioma) have a poor prognosis. Consequently, there is an unmet clinical need for accessible and noninvasively acquired predictive biomarkers of overall survival in patients. This study evaluated morphological changes in the brain separated from the tumor invasion site (ie, contralateral hemisphere). Specifically, we examined the prognostic value of widespread alterations of cortical thickness (CT) in GBM/HGG patients.

Methods

We used FreeSurfer, applied with high-resolution T1-weighted MRI, to examine CT, evaluated prior to standard treatment with surgery and chemoradiation in patients (GBM/HGG, N = 162, mean age 61.3 years) and 127 healthy controls (HC; 61

SUBMITTER: Lamichhane B 

PROVIDER: S-EPMC10162111 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature