Remodeling of E-cadherin subcellular localization during cell dissemination.

ABSTRACT: Given the role of E-cadherin (E-cad) in holding epithelial cells together, an inverse relationship between E-cad levels and cell invasion during the epithelial-mesenchymal transition and cancer metastasis has been well recognized. Here we report that E-cad is necessary for the invasiveness of Ras^V12-transformed intestinal epithelial cells in Drosophila. E-cad/β-catenin disassembles at adherens junctions and assembles at invasive protrusions--the actin- and cortactin-rich invadopodium-like protrusions associated with the breach of the extracellular matrix (ECM)--during dissemination of Ras^V12-transformed intestinal epithelial cells. Loss of E-cad impairs the elongation of invasive protrusions and attenuates the ability of Ras

SUBMITTER: Cabrera AJH 

PROVIDER: S-EPMC10162421 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature