Unique molecular signatures sustained in circulating monocytes and regulatory T cells in convalescent COVID-19 patients.

ABSTRACT: Over two years into the COVID-19 pandemic, the human immune response to SARS-CoV-2 during the active disease phase has been extensively studied. However, the long-term impact after recovery, which is critical to advance our understanding SARS-CoV-2 and COVID-19-associated long-term complications, remains largely unknown. Herein, we characterized single-cell profiles of circulating immune cells in the peripheral blood of 100 patients, including convalescent COVID-19 and sero-negative controls. Flow cytometry analyses revealed reduced frequencies of both short-lived monocytes and long-lived regulatory T (Treg) cells within the patients who have recovered from severe COVID-19. sc-RNA seq analysis identifies seven heterogeneous clusters of monocytes and nine Treg clusters featuring distinct mo

SUBMITTER: Hoffmann AD 

PROVIDER: S-EPMC10162478 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature