Lipoprotein subfraction profiling in the search of new risk markers for myocardial infarction: The HUNT study.

ABSTRACT:

Background

Traditional biomarkers used to measure risk of myocardial infarction (MI) only explain a modest proportion of the incidence. Lipoprotein subfractions have the potential to improve risk prediction of MI.

Aim

We aimed to identify lipoprotein subfractions that were associated with imminent MI risk.

Methods

We identified apparently healthy participants with a predicted low 10-year risk of MI from The Trøndelag Health Survey 3 (HUNT3) that developed MI within 5 years after inclusion (cases, n = 50) and 100 matched controls. Lipoprotein subfractions were analyzed in serum by nuclear magnetic resonance spectroscopy at time of inclusion in HUNT3. Lipoprotein subfractions were compared between cases and controls in the full population (N = 150), and in subgroups of

SUBMITTER: Sperstad SB 

PROVIDER: S-EPMC10162525 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature