Associations between cognitive function and endogenous levels of estradiol and testosterone in adults with type 2 diabetes.

ABSTRACT:

Aims

To assess associations that endogenous estradiol and testosterone levels have with cognitive function in older adults with Type 2 diabetes mellitus (T2DM).

Methods

We use data from the Look AHEAD clinical trial of behavioral weight loss. Endogenous estradiol and total testosterone levels were determined using stored serum from 996 individuals, mean age 69 years, at two times (averaging 4 years apart) during years 8-18 of follow-up. One to four standardized assessments of attention, executive function, memory, and verbal fluency were collected during this follow-up. Mixed effects models and multiple imputation were used to assess associations that estradiol and total testosterone levels had with body mass index and cognitive function.

Results

Estradiol levels were

SUBMITTER: Espeland MA 

PROVIDER: S-EPMC10162709 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature