Two enhancer binding proteins activate σ⁵⁴-dependent transcription of a quorum regulatory RNA in a bacterial symbiont.

ABSTRACT: To colonize a host, bacteria depend on an ensemble of signaling systems to convert information about the various environments encountered within the host into specific cellular activities. How these signaling systems coordinate transitions between cellular states in vivo remains poorly understood. To address this knowledge gap, we investigated how the bacterial symbiont Vibrio fischeri initially colonizes the light organ of the Hawaiian bobtail squid Euprymna scolopes. Previous work has shown that the small RNA Qrr1, which is a regulatory component of the quorum-sensing system in V. fischeri, promotes host colonization. Here, we report that transcriptional activation of Qrr1 is inhibited by the sensor kinase BinK, which suppresses cellular aggregation by V. fischeri

SUBMITTER: Surrett ED 

PROVIDER: S-EPMC10162802 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature