Dataset Information

Perfluoroalkyl substances in Baltic fish - the risk to consumers.

ABSTRACT: Perfluoroalkyl substances (PFASs) were investigated in five Baltic fish species (sprat, herring, salmon, trout, and cod). Each species' median lower bound (LB) concentration of ∑14 PFASs was as follows: in sprat it was 3.54 µg/kg wet weight (w.w.), in cod 2.15 µg/kg w.w., in salmon 2.10 µg/kg w.w., in trout 2.03 µg/kg w.w. and in herring 1.74 µg/kg w.w.. Regarding the species' median LB of ∑4 PFASs (perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorohexane sulfonic acid (PFHxS)), sprat was the most contaminated with 2.90 µg/kg w.w. and herring was the least with 1.17 µg/kg w.w.. Among all PFASs, PFOS was found in the highest concentrations (range 0.04-9.16 µg/kg w.w.) and the percentage share in the total concentration of ∑14 PFASs was between 56 and 73%. The average proportion of linear PFOS (L-PFOS) in the total PFOS (branched and linear) was the highest in salmon at 89% and trout at 87%, and in the other three species it ranged from 75 to 80%. Different consumption scenarios were assumed and the intake of PFASs was calculated for children and adults. Dietary intake via fish consumption was 3.20-25.13 ng/kg of body weight (b.w.) for children and 1.68-8.30 ng/kg b.w. for adults. Baltic fish caught along Polish coastal areas are a significant source of PFASs, especially for children.

SUBMITTER: Mikolajczyk S

PROVIDER: S-EPMC10163105 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Perfluoroalkyl substances in Baltic fish - the risk to consumers.

Mikolajczyk Szczepan S Warenik-Bany Malgorzata M Pajurek Marek M

Environmental science and pollution research international 20230403 21

Perfluoroalkyl substances (PFASs) were investigated in five Baltic fish species (sprat, herring, salmon, trout, and cod). Each species' median lower bound (LB) concentration of ∑14 PFASs was as follows: in sprat it was 3.54 µg/kg wet weight (w.w.), in cod 2.15 µg/kg w.w., in salmon 2.10 µg/kg w.w., in trout 2.03 µg/kg w.w. and in herring 1.74 µg/kg w.w.. Regarding the species' median LB of ∑4 PFASs (perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA ...[more]

PMID: 37012565

Similar Datasets

Project description:Background & aimsExposure to poly- and perfluoroalkyl substances (PFAS), a class of persistent organic pollutants, is ubiquitous. Animal studies suggest that PFAS may increase risk of fatty liver and hepatocellular carcinoma (HCC) via impacts on hepatic lipid, amino acid, and glucose metabolism, but human data is lacking. We examined associations between PFAS exposure, altered metabolic pathways, and risk of non-viral HCC.MethodsIn this nested case-control study, pre-diagnostic plasma PFAS and metabolomics were measured in 50 incident HCC cases and 50 individually matched controls from the Multiethnic Cohort (MEC) study. Cases/controls were matched by age, sex, race, and study area. PFAS exposure and risk of HCC were examined using conditional logistic regression. A metabolome-wide association study and pathway enrichment analysis was performed for PFAS exposure and HCC risk, and key metabolites/metabolic pathways were identified using a meet in the middle approach.ResultsHigh perfluorooctane sulfonic acid (PFOS) levels (90th percentile from NHANES; >55 μg/L) were associated with 4.5-fold increased risk of HCC (odds ratio 4.5, 95% CI 1.2-16.0). Pathway enrichment analysis showed that PFOS exposure was associated with alterations in amino acid and glycan biosynthesis pathways, which were also associated with HCC risk. We identified 4 metabolites linking PFOS exposure with HCC, including glucose, butyric acid (a short-chain fatty acid), α-ketoisovaleric acid (a branched-chain α-keto acid), and 7α-hydroxy-3-oxo-4-cholestenoate (a bile acid), each of which was positively associated with PFOS exposure and risk of HCC.ConclusionThis proof-of-concept analysis shows that exposure to high PFOS levels was associated with increased risk of non-viral HCC, likely via alterations in glucose, amino acid, and bile acid metabolism. Larger studies are needed to confirm these findings.Lay summaryPer- and polyfluoroalkyl substances (PFAS), often referred to as "forever chemicals" because they are difficult to break down and stay in the human body for years, are extremely common and can cause liver damage. In a first of its kind study, we found that exposure to high levels of perfluorooctanesulfonic acid, one of the most common PFAS chemicals, was linked to increased risk of hepatocellular carcinoma in humans. Hepatocellular carcinoma is difficult to treat and is one of the most common forms of liver cancer, and these findings may provide new avenues for helping to prevent this disease.

Dataset Information

Perfluoroalkyl substances in Baltic fish - the risk to consumers.

Publications

Perfluoroalkyl substances in Baltic fish - the risk to consumers.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets