Implementation of dihydropyrimidine dehydrogenase deficiency testing in Europe.

ABSTRACT:

Background

The main cause for fluoropyrimidine-related toxicity is deficiency of the metabolizing enzyme dihydropyrimidine dehydrogenase (DPD). In 2020, the European Medicines Agency (EMA) recommended two methods for pre-treatment DPD deficiency testing in clinical practice: phenotyping using endogenous uracil concentration or genotyping for DPYD risk variant alleles. This study assessed the DPD testing implementation status in Europe before (2019) and after (2021) the release of the EMA recommendations.

Methods

The survey was conducted from 16 March 2022 to 31 July 2022. An electronic form with seven closed and three open questions was e-mailed to 251 professionals with DPD testing expertise of 34 European countries. A descriptive analysis was conducted.

Results

We r

SUBMITTER: de With M 

PROVIDER: S-EPMC10163157 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature