New, fast and cheap prediction tests for BRCA1 gene mutations identification in clinical samples.

ABSTRACT: Despite significant progress in cancer therapy, cancer is still the second cause of mortality in the world. The necessity to make quick therapeutic decisions forces the development of procedures allowing to obtain a reliable result in a quick and unambiguous manner. Currently, detecting predictive mutations, including BRCA1, is the basis for effectively treating advanced breast cancer. Here, we present new insight on gene mutation detection. We propose a cheap BRCA1 mutation detection tests based on the surface plasmon resonance (SPR) or quartz crystal microbalance with energy dissipation (QCM-D) response changes recorded during a hybridization process of an oligonucleotide molecular probe with DNA fragments, with and without the BRCA1 mutation. The changes in the morphology of the formed

SUBMITTER: Gajda-Walczak A 

PROVIDER: S-EPMC10163215 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature