Efficacy and safety of ceftazidime-avibactam versus polymyxins in the treatment of carbapenem-resistant Enterobacteriaceae infection: a systematic review and meta-analysis.

ABSTRACT:

Objectives

Carbapenem-resistant Enterobacteriaceae is increasingly recognised as a significant public health concern. Ceftazidime-avibactam (CAZ-AVI) and polymyxins are considered as the last therapeutic options worldwide. This is the first meta-analysis of recently published data to compare the clinical efficacy and safety of CAZ-AVI with polymyxins in the treatment of carbapenem-resistant Enterobacteriaceae infections.

Design

Systematic review and meta-analysis.

Data sources

PubMed, Embase and the Cochrane Library were systematically searched, for publications in any language, from database inception to February 2023.

Eligibility criteria for selecting studies

Studies comparing the clinical efficacy and safety of CAZ-AVI with polymyxins were included. Mortali

SUBMITTER: Yang P 

PROVIDER: S-EPMC10163451 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature