Nanomaterials with dual immunomodulatory functions for synergistic therapy of breast cancer brain metastases.

ABSTRACT: A long-standing paucity of effective therapies results in the poor outcomes of triple-negative breast cancer brain metastases. Immunotherapy has made progress in the treatment of tumors, but limited by the non-immunogenicity of tumors and strong immunosuppressive environment, patients with TNBC brain metastases have not yet benefited from immunotherapy. Dual immunoregulatory strategies with enhanced immune activation and reversal of the immunosuppressive microenvironment provide new therapeutic options for patients. Here, we propose a cocktail-like therapeutic strategy of microenvironment regulation-chemotherapy-immune synergistic sensitization and construct reduction-sensitive immune microenvironment regulation nanomaterials (SIL@T). SIL@T modified with targeting peptide penetrates the BB

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC10163467 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature