Association of uric acid with the decline in estimated glomerular filtration rate in middle-aged and elderly populations: evidence based on the China Health and Retirement Longitudinal Study.

ABSTRACT:

Objective

Whether uric acid (UA) has an effect on renal function remains controversial. We aimed to investigate the association between serum UA with the decline in estimated glomerular filtration rate (eGFR) in middle-aged and elderly populations in the China Health and Retirement Longitudinal Study (CHARLS).

Design

Longitudinal cohort study.

Setting

This was a second analysis of a public dataset (CHARLS).

Participants

In this study, 4538 middle-aged and elderly individuals were screened after removing individuals younger than 45 years old, with kidney disease, malignant tumour and missing values.

Outcome measures

Blood tests were performed both in 2011 and 2015. Decline in eGFR was defined as an eGFR decrease of more than 25% or deterioration of the eG

SUBMITTER: Liu P 

PROVIDER: S-EPMC10163514 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature