Multi-pathogen based chimeric vaccine to fight against COVID-19 and concomitant coinfections.

ABSTRACT:

Background

COVID-19 has proved to be a fatal disease of the year 2020, due to which thousands of people globally have lost their lives, and still, the infection cases are at a high rate. Experimental studies suggested that SARS-CoV-2 interacts with various microorganisms, and this coinfection is accountable for the augmentation of infection severity.

Methods and results

In this study, we have designed a multi-pathogen vaccine by involving the immunogenic proteins from S. pneumonia, H. influenza, and M. tuberculosis, as they are dominantly associated with SARS-CoV-2. A total of 8 antigenic protein sequences were selected to predict B-cell, HTL, and CTL epitopes restricted to the most prevalent HLA alleles. The selected epitopes were antigenic, non-allergenic, and non-toxic an

SUBMITTER: Ojha R 

PROVIDER: S-EPMC10163573 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature