Randomised trial of stable chest pain investigation: 3-year clinical and quality of life results from CE-MARC 2.

ABSTRACT:

Aims

Guidelines for suspected cardiac chest pain have used historical risk stratification tools, advocating invasive coronary angiography (ICA) first-line in those at highest risk. We aimed to determine whether different strategies to manage suspected stable angina affected medium-term cardiovascular event rates and patient-reported quality of life (QoL) measures.

Methods

CE-MARC 2, a three-arm parallel group trial, randomised patients with suspected stable cardiac chest pain and a Duke Clinical pretest likelihood of coronary artery disease between 10% and 90%. Patients were randomised to either first-line cardiovascular magnetic resonance (CMR), single-photon emission computed tomography (SPECT) or the UK National Institute for Health and Care Excellence (NICE) CG95 (2010)

SUBMITTER: Everett CC 

PROVIDER: S-EPMC10163591 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature