CD73 and PD-L1 dual blockade amplifies antitumor efficacy of SBRT in murine PDAC models.

ABSTRACT:

Background

Stereotactic body radiotherapy (SBRT) induces immunogenic cell death, leading to subsequent antitumor immune response that is in part counterbalanced by activation of immune evasive processes, for example, upregulation of programmed cell death-ligand 1 (PD-L1) and adenosine generating enzyme, CD73. CD73 is upregulated in pancreatic ductal adenocarcinoma (PDAC) compared with normal pancreatic tissue and high expression of CD73 in PDACs is associated with increased tumor size, advanced stage, lymph node involvement, metastasis, PD-L1 expression and poor prognosis. Therefore, we hypothesized that blockade of both CD73 and PD-L1 in combination with SBRT might improve antitumor efficacy in an orthotopic murine PDAC model.

Methods

We assessed the combination of systemic

SUBMITTER: Ye J 

PROVIDER: S-EPMC10163599 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature