A novel gene, TARDBP, and the protein it encodes can predict glioma patient prognosis and establish a prediction model.

ABSTRACT:

Background

TDP-43 (43-kD transactive response DNA-binding protein) is a DNA-/RNA-binding protein that plays an important role in several nervous system diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Whether it plays an important role in glioma patients is unknown.

Methods

Datasets were downloaded from the Chinese Glioma Genome Atlas (CGGA) website ( http://www.cgga.org.cn/ ). Cox survival analysis was performed to determine the relationship between TARDBP gene expression and the overall survival of glioma patients. GO analyses were performed to determine the biological functions of the TARDBP gene. Finally, we used PRS type, age, grade, IDH mutation status, 1p/19q codeletion status, and expression value of the TARDBP gene to construc

SUBMITTER: Fang X 

PROVIDER: S-EPMC10163712 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature