Sp1 promotes tumour progression by remodelling the mitochondrial network in cervical cancer.

ABSTRACT:

Background

Cervical cancer remains one of the most prevalent cancers worldwide. Accumulating evidence suggests that specificity protein 1 (Sp1) plays a pivotal role in tumour progression. The underlying role and mechanism of Sp1 in tumour progression remain unclear.

Methods

The protein level of Sp1 in tumour tissues was determined by immunohistochemistry. The effect of Sp1 expression on the biological characteristics of cervical cancer cells was assessed by colony, wound healing, transwell formation, EdU, and TUNEL assays. Finally, the underlying mechanisms and effects of Sp1 on the mitochondrial network and metabolism of cervical cancer were analysed both in vitro and in vivo.

Results

Sp1 expression was upregulated in cervical cancer. Sp1 knockdown suppressed cell pr

SUBMITTER: Xu X 

PROVIDER: S-EPMC10163764 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature