Gene expression of male pathway genes sox9 and amh during early sex differentiation in a reptile departs from the classical amniote model.

ABSTRACT:

Background

Sex determination is the process whereby the bipotential embryonic gonads become committed to differentiate into testes or ovaries. In genetic sex determination (GSD), the sex determining trigger is encoded by a gene on the sex chromosomes, which activates a network of downstream genes; in mammals these include SOX9, AMH and DMRT1 in the male pathway, and FOXL2 in the female pathway. Although mammalian and avian GSD systems have been well studied, few data are available for reptilian GSD systems.

Results

We conducted an unbiased transcriptome-wide analysis of gonad development throughout differentiation in central bearded dragon (Pogona vitticeps) embryos with GSD. We found that sex differentiation of transcriptomic profiles occurs at a very early stage, before th

SUBMITTER: Wagner S 

PROVIDER: S-EPMC10163765 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature