Entorhinal cortex epigenome-wide association study highlights four novel loci showing differential methylation in Alzheimer's disease.

ABSTRACT:

Background

Studies on DNA methylation (DNAm) in Alzheimer's disease (AD) have recently highlighted several genomic loci showing association with disease onset and progression.

Methods

Here, we conducted an epigenome-wide association study (EWAS) using DNAm profiles in entorhinal cortex (EC) from 149 AD patients and control brains and combined these with two previously published EC datasets by meta-analysis (total n = 337).

Results

We identified 12 cytosine-phosphate-guanine (CpG) sites showing epigenome-wide significant association with either case-control status or Braak's tau-staging. Four of these CpGs, located in proximity to CNFN/LIPE, TENT5A, PALD1/PRF1, and DIRAS1, represent novel findings. Integrating DNAm levels with RNA sequencing-based mRNA expression data

SUBMITTER: Sommerer Y 

PROVIDER: S-EPMC10163801 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature