SARS-CoV-2 infection and recovery in children: Distinct T cell responses in MIS-C compared to COVID-19.

ABSTRACT: SARS-CoV-2 infection for most children results in mild or minimal symptoms, though in rare cases severe disease can develop, including a multisystem inflammatory syndrome (MIS-C) with myocarditis. Here, we present longitudinal profiling of immune responses during acute disease and following recovery in children who developed MIS-C, relative to children who experienced more typical symptoms of COVID-19. T cells in acute MIS-C exhibited transient signatures of activation, inflammation, and tissue residency which correlated with cardiac disease severity, while T cells in acute COVID-19 upregulated markers of follicular helper T cells for promoting antibody production. The resultant memory immune response in recovery showed increased frequencies of virus-specific memory T cells with pro-inflam

SUBMITTER: Rybkina K 

PROVIDER: S-EPMC10163842 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature