Pathological mechanism of heart failure with preserved ejection fraction in rats based on iTRAQ technology.

ABSTRACT:

Objective

Heart failure with preserved ejection fraction (HFpEF) is a public health problem worldwide. Treatments for the patients with HFpEF are not satisfactory because there is no unified understanding of the pathological mechanism of HFpEF. This study aims at investigating the potential pathological mechanism for the effective diagnosis and treatment of HFpEF.

Methods

Ten adult male Dahl salt sensitive rats (180-200 g) were divided into control and model groups. The rats in model group were fed with high salt diet (8% NaCl) to induce HFpEF for this comparative study. Behavioral changes, biochemical parameters, and histopathological changes of the rats were detected. iTRAQ technology combined with bioinformatics analysis was employed to study the differentially expressed

SUBMITTER: Xu H 

PROVIDER: S-EPMC10163871 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature