Circulating lipoprotein (a) and all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis.

ABSTRACT:

Aims

To investigate the association between circulating lipoprotein(a) (Lp(a)) and risk of all-cause and cause-specific mortality in the general population and in patients with chronic diseases, and to elucidate the dose-response relations.

Methods and results

We searched literature to find prospective studies reporting adjusted risk estimates on the association of Lp(a) and mortality outcomes. Forty-three publications, reporting on 75 studies (957,253 participants), were included. The hazard ratios (HRs) and 95% confidence intervals (95%CI ) for the top versus bottom tertile of Lp(a) levels and risk of all-cause mortality were 1.09 (95%CI: 1.01-1.18, I²: 75.34%, n = 19) in the general population and 1.18 (95%CI: 1.04-1.34, I²: 52.5%, n = 12) in patient

SUBMITTER: Amiri M 

PROVIDER: S-EPMC10164031 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature