Intensive versus standard blood pressure control in older persons with or without diabetes: a systematic review and meta-analysis of randomised controlled trials.

ABSTRACT:

Objectives

To assess and compare the benefits and harms of intensive versus standard blood pressure (BP) control in older people with or without diabetes mellitus (DM).

Design

Systematic review and meta-analysis.

Setting

Randomised controlled trials comparing intensive versus standard BP control, identified from MEDLINE, Embase, The Cochrane library, Web of Science and a search of bibliographies from inception till August 2022.

Participants

Older people (≥65 years) with or without DM.

Main outcome measures

Study-specific risk ratios (RRs) with 95% confidence intervals (CIs) were pooled for adverse vascular and safety outcomes.

Results

We included six randomised controlled trials (RCTs) comprising 20,985 patients (intensive BP = 10,474 and standard

SUBMITTER: Seidu S 

PROVIDER: S-EPMC10164272 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature