The relationship between adipokine levels and bone mass-A systematic review.

ABSTRACT:

Introduction

Adipose tissue is the source of a broad array of signalling molecules (adipokines), which mediate interorgan communication and regulate metabolic homeostasis. Alterations in adipokine levels have been causally implicated in various metabolic disorders, including changes in bone mass. Osteoporosis is the commonest progressive metabolic bone disease, characterized by elevated risk of fragility fractures as a result of a reduced bone mass and microarchitectural deterioration. The effects of different adipokines on bone mass have been studied in an attempt to identify novel modulators of bone mass or diagnostic biomarkers of osteoporosis.

Methods

In this review, we sought to aggregate and assess evidence from independent studies that quantify specific adipokines and

SUBMITTER: Mangion D 

PROVIDER: S-EPMC10164433 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature