Repeated motor cortex theta-burst stimulation produces persistent strengthening of corticospinal motor output and durable spinal cord structural changes in the rat.

ABSTRACT:

Background

The strength of connections between motor cortex (MCX) and muscle can be augmented with a variety of stimulation protocols. Augmenting MCX-to-muscle connection strength by neuromodulation may be a way to enhance the intact motor system's capacity for acquiring motor skills and promote function after injury to strengthen spared connections. But this enhancement must be maintained for functional improvements.

Objective

We determined if brief MCX muscle evoked potential (MEP) enhancement produced by single-block intermittent theta burst stimulation (iTBS) can be converted into a longer and structurally durable form of response enhancement with repeated daily and longer-term application.

Methods

Electrical iTBS was delivered through an implanted MCX epidural el

SUBMITTER: Amer A 

PROVIDER: S-EPMC10164459 | biostudies-literature | 2022 Jul-Aug

REPOSITORIES: biostudies-literature