Genetic Variants Associated with Supernormal Coronary Arteries.

ABSTRACT:

Aims

Genetic and medical insights from studies on cardioprotective phenotypes aid the development of novel therapeutics. This study identified genetic variants associated with supernormal coronary arteries using genome-wide association study data and the corresponding genes based on expression quantitative trait loci (eQTL).

Methods

Study participants were selected from two Korean cohorts according to inclusion criteria that included males with high cardiovascular risk (Framingham risk score ≥ 14, 10-year risk ≥ 16%) but with normal coronary arteries (supernormal group) or coronary artery disease (control group). After screening 12,309 individuals, males meeting the supernormal phenotype (n=72) and age-matched controls (n=94) were enrolled. Genetic variants associated with t

SUBMITTER: Kim B 

PROVIDER: S-EPMC10164599 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature