Rates of clinical remission and inadequate response to advanced therapies among patients with ulcerative colitis in Germany.

ABSTRACT:

Purpose

Many patients treated for ulcerative colitis (UC) do not achieve clinical remission. This real-world study assessed clinical remission and inadequate response rates among patients with UC in Germany treated with advanced therapies.

Methods

This retrospective chart review included patients with UC newly initiating advanced (index) therapy (anti-TNFα agents, vedolizumab, tofacitinib) from January 2017-September 2019 (index date). Included patients had data for ≥ 12 months before (baseline period) and after the index date (follow-up period). Remission was defined as a partial Mayo score ≤ 1. Indicators of inadequate response were: index therapy discontinuation; therapy adjustments (index therapy dose escalation; augmentation with non-advanced therapies; corticosteroid [

SUBMITTER: Bokemeyer B 

PROVIDER: S-EPMC10164668 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature