Defining Treatment Response for Clinical Trials of Pediatric Acute Asthma.

ABSTRACT:

Background

An agreed-upon definition of treatment response for clinical trials of pediatric acute asthma does not exist, limiting meaningful comparisons among therapeutic interventions and advances in asthma management.

Objective

To develop a consensus definition of treatment response for clinical trials of pediatric acute asthma.

Methods

A multidisciplinary panel of 22 experts participated in a Web-based modified Delphi process to achieve consensus on a definition of treatment response. Round 1 consisted of closed- and open-ended questions in which panelists ranked measures of treatment response developed by literature review, suggested additional measures, and explained their responses. In rounds 2 and 3, panelists reviewed summary statistics of the panel's rating f

SUBMITTER: Navanandan N 

PROVIDER: S-EPMC10164688 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature