Improving the anti-tumor effect of EGCG in colorectal cancer cells by blocking EGCG-induced YAP activation.
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ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC10164806 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
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Improving the anti-tumor effect of EGCG in colorectal cancer cells by blocking EGCG-induced YAP activation.
Wang Yu Y Jin Sha-Sha SS Li Dan-Ting DT Jiang Xiao-Chun XC Afrasiyab Khalid Anam A Liu Xin X Wang Hui-Lin HL Wang Hai-Yan HY Wang Zai-Gui ZG Xie Zhong-Wen ZW Huang Shou-Jun SJ
American journal of cancer research 20230415 4
(-)-Epigallocatechin-3-gallate (EGCG) is the primary active ingredient in green tea and has been used for cancer prevention in clinical trials. The anti-tumor effects of EGCG stem from its ability to inhibit the activities of many oncoproteins, such as AKT, VEGFR, STAT3, and mutant p53. However, the clinical efficacy of EGCG is unsatisfactory. How to improve the anti-tumor effects of EGCG is an open question. Here we report that EGCG inhibits the tumor suppressive Hippo signaling pathway and act ...[more]
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