CENtral blood pressure Targeting: a pragmatic RAndomized triaL in advanced Chronic Kidney Disease (CENTRAL-CKD): A Clinical Research Protocol.

ABSTRACT:

Background

Emerging data favor central blood pressure (BP) over brachial cuff BP to predict cardiovascular and kidney events, as central BP more closely relates to the true aortic BP. Considering that patients with advanced chronic kidney disease (CKD) are at high cardiovascular risk and can have unreliable brachial cuff BP measurements (due to high arterial stiffness), this population could benefit the most from hypertension management using central BP measurements.

Objective

To assess the feasibility and efficacy of targeting central BP as opposed to brachial BP in patients with CKD G4-5.

Design

Pragmatic multicentre double-blinded randomized controlled pilot trial.

Setting

Seven large academic advanced kidney care clinics across Canada.

Patients

A tot

SUBMITTER: Goupil R 

PROVIDER: S-EPMC10164859 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature