Long-term effect of Helicobacter pylori eradication on colorectal cancer incidences.

ABSTRACT:

Background

There is evidence supporting the association between Helicobacter pylori infection and colorectal cancer (CRC), but whether H. pylori eradication reduces the risk of CRC is still unknown.

Objectives

To compare the incidence of CRC in subjects who had received H. pylori eradication therapy with general population.

Design

A population-based retrospective cohort study.

Methods

This study included all H. pylori-infected subjects who had received their first course of clarithromycin-containing triple therapy in 2003-2015 in Hong Kong. We compared the observed incidences of CRC in this H. pylori eradicated cohort with the expected incidences in the age- and sex-matched general population. The standardized incidence ratio

SUBMITTER: Guo CG 

PROVIDER: S-EPMC10164860 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature