Colorectal surveillance outcomes from an institutional longitudinal cohort of lynch syndrome carriers.

ABSTRACT:

Objective

Lynch Syndrome (LS) carriers have a significantly increased risk of developing colorectal cancer (CRC) during their lifetimes. Further stratification of this patient population may help in identifying additional risk factors that predispose to colorectal carcinogenesis. In most LS patients CRC may arise from adenomas, although an alternative non-polypoid carcinogenesis pathway has been proposed for PMS2 carriers. Using data from our institutional LS cohort, our aim was to describe our current colorectal screening outcomes with a focus on the incidence of adenomas in the context of different MMR genotypes and patient demographics such as gender, race, and ethnicity.

Design

We collected demographics, genetic, colonoscopy, and pathology results from a total of

SUBMITTER: Del Carmen G 

PROVIDER: S-EPMC10164917 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature